Remarkably, expression of the two paralogs NAB1 and NAB2 (co-transcriptional regulators that inhibit EGR2 function) are detected at lower levels in the post-mortem cerebellum (Figure 6f), confirming impairment of the NAB1/2/EGR2 axis in RTT patients and suggesting the molecular basis for aberrant myelination. The gene discussed is NAB2; the disease is Rett syndrome.