CLOCK and fatty liver disease: Indeed, in a recent review, Mukherji et al. highlighted the importance of the circadian clock in liver function and fatty liver disease [25], and our findings imply a complex interplay between diclofenac, the liver clock and the hypothalamic–pituitary–adrenal axis with stress-induced adrenocorticopic hormone (ACTH) release augmenting adrenal glucocorticoid synthesis to modulate the immune response.