Based on the observed expression induction rates of CD11b, CD83, and CXCR4 as well as the IL-12p40 expression upon sensitizer treatment and the phagocytotic capability, our iDC and mDC surrogates are beneficial to study the molecular mechanisms of dendritic cell-mediated phagocytosis [73,100], dendritic cell maturation [101], as well as migration [22] and, furthermore, their use as therapeutic model systems in various disorders, such as sensitization, inflammation [102,103], as well as cancer [104] and the tumor microenvironment [105], should not be discounted. This evidence concerns the gene CXCR4 and neoplasm.