Interestingly, MAT2A and MAT2B, two enzymes from the methionine cycle—that converts methionine to SAM—were found to be upregulated in the blood of TD patients aged 13–16 [66], while the landscape proteins PRMT1 and AHCY catalyze the subsequent conversion of SAM to SAH and SAH to homocysteine, respectively. The gene discussed is AHCY; the disease is thanatophoric dysplasia.