CX3CR1 expression is upregulated in the blood of TD patients aged 10–12 years (FC = 1.18) [66] and in mouse striatum, Cx3cr1 shows a temporal expression pattern corresponding to developmental stages that could be linked to TD occurrence and resolution (i.e., first upregulation, then downregulation) [248]. This evidence concerns the gene CX3CR1 and thanatophoric dysplasia.