ITGB1 and thanatophoric dysplasia: Moreover, CX3CR1 and CX3CL1 have molecular specificity for TD, and this not only through forming a functional complex with each other but also through additional effects of CXC3L1 on multiple other landscape proteins—that were not all drawn in the landscape but can be found in Table S5—e.g., as a ligand of the ITGA4-ITGB1-complex and through upregulating the expression of extracellular POSTN and membrane-located CDHR1.