As for its temporal specificity, HRH2 expression is upregulated in the blood of TD patients aged 10–12 years (FC = 1.12) [66] and in mouse striatum, Hrh2 shows a temporal expression pattern corresponding to developmental stages that could be linked to TD occurrence and resolution (i.e., first upregulation, then downregulation) [248]. This evidence concerns the gene HRH2 and thanatophoric dysplasia.