PIM1 and thanatophoric dysplasia: For example, upon binding its ligand, the cytokine FLT3LG—which has been linked to TD as well, as FLT3LG blood expression is positively correlated with TD symptom severity [67]—regulates the phosphorylation of MAPK3 and MAPT, two highly interactive landscape proteins, while it also regulates the expression of cytoplasmic PIM1 and nuclear EXCC6, two proteins that (also) interact with many other landscape proteins.