In the brain, BA can act as a regulator of the immune response through its anti-inflammatory actions in microglia [209], an epigenetic regulator that increases gene expression through inhibiting histone deacetylation [210,211] and/or as an endogenous ligand for a subset of GPCRs, including the landscape protein FFAR3 and—not shown in the landscape—FFAR2 (upregulated in postmortem TD brain) [64] and HCAR2 (of which the blood expression is negatively correlated with TD severity) [67]. This evidence concerns the gene FFAR3 and thanatophoric dysplasia.