LEP and neoplasm: Upon “in vitro” leptin stimulation, there is an increase in the expression of miR-21, miR-96, miR-31, and miR-182, reported to have oncogenic actions which have been reported, such as oncogenic miRNAs; in addition, leptin reduces tumor suppressor miRNAs (miR-143, miR-26b, miR-27b, miR-489) [78].