SOCS3 and hepatocellular carcinoma: The leptin signaling cascade can be involved in changes in susceptibility to cancer processes and it has been suggested that genetic variations in JAK2 are involved in the generation of several signs of myeloproliferative neoplasms [227], as well as SOCS3 polymorphisms, that may favor the progression towards liver fibrosis and hepatocellular carcinoma [228].