The reported main molecular signaling pathways attending the pathogenesis of the CSCs of HCC include the Wnt/β-catenin, transforming growth factors-β (TGF-β), sonic hedgehog (SHH), PI3K/Akt/mTOR and Notch pathways [40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.