The Wnt/β-catenin signaling pathway triggers angiogenesis, tumor infiltration and metastasis through the enhancement of angiogenic factors, such as matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and VEGF-C [91]. Here, MMP2 is linked to neoplasm.