PROM1 and hepatocellular carcinoma: Then, they isolated the CD133-positive cells to analyze the cell viability, apoptosis, migration, spheroid formation and expressions of genes and proteins, finding that Notch inhibition sensitized the HCC CD133-positive cells to VIN and 5-FU via enhancing B-cell lymphoma 2 (BCL2)-binding component (BBC3-3)-mediated apoptosis [111].