In a swine model of LPS-induced AKI, pericyte-to-myofibroblast transdifferentiation (PMT) was observed within 9 h after LPS challenge, as evaluated by the reduction of physiologic platelet-derived growth factor receptor beta (PDGFRβ) expression and the dysfunctional α-SMA increase in peritubular pericyte. Here, PDGFRB is linked to acute kidney injury.