Similar to comparing the pathways found to be significant in different contrasts, such as (c) MEN-pre vs. healthy and (d) MEN-post vs. healthy, as above, a direct analysis of the contrast (f) MEN-pre vs. MEN-post placed the infectious disease pathway at the top of the signaling pathways, with 34 DIRAGS identified in MEN-pre as more highly reactive, followed by L13a-mediated translational silencing of ceruloplasmin expression and GTP hydrolysis, and joining of the 60S ribosomal subunit pathways (each presented by 11 antigens). Here, CP is linked to infectious disease.