Of 28 antigens present in the axon guidance pathway, 9 (DPYSL2, UBB, MYH10, USP33, ANK3, SPTAN1, SH3GL2, ITSN1 and AP2M1) were overexpressed in healthy individuals, and 13 (GPC1, RPL36A, RPS9, RPS2, ROBO3, RPL27, MYL6, RPS15, RPS18, TUBA1A, RPL13, RPS21 and ACTG1) were overexpressed in GBM tissue. This evidence concerns the gene RPS21 and glioblastoma.