Of the 29 antigens that are higher reactive in GBM-pre, and represent the signaling by the Rho GTPases, Miro GTPases and RHOBTB3 pathways, the retrieved 8 genes (LMNB1, NCKAP1L, ACTG1, PPP1CC, ARHGEF10L, MYO19, CCT6A, TAX1BP3) were significantly overexpressed. The gene discussed is PPP1CC; the disease is glioblastoma.