Other interesting factors discovered in this finding were that PrP silencing in glioma cell lines causes increased autophagy due to induction of LC3-II, an increase in Beclin 1, and simultaneous decreases in p62, Bcl-2, and the phosphorylation of 4E-BP1, a target of mTOR autophagy signaling [47]. The gene discussed is PRNP; the disease is central nervous system cancer.