Furthermore, it has been demonstrated that the disruption of the equilibrium between the anabolic/catabolic ratio may be caused by upregulation of a lipogenesis enzyme, such as DGAT1, loss of prolipolytic mediators, such as adipose triglyceride lipase (ATGL) and pigment epithelium-derived factor (PEDF), also denominated as serpin F1 (SERPINF1), or both, resulting with increased intratumoral lipid content, which is associated with augmented tumor aggressiveness [63]. Here, PNPLA2 is linked to neoplasm.