In addition, genetic analyses showed that miR-19 is involved in two T-ALL-associated gene rearrangements, comprising T-cell receptor α/γ (TRA/D) locus (t13;14)(q32;q11) and NOTCH1 locus t(9;14)(q34;q11), the latter generating a constitutively active form of NOTCH1. Here, NOTCH1 is linked to acute lymphoblastic leukemia.