In contrast to the aforementioned miRNAs, miR-30a exhibits tumor-suppressive properties in vitro and inhibits NOTCH1 and NOTCH2 expression in an MYC-dependent manner, and it was also found to participate in a bidirectional regulatory circuitry between NOTCH and MYC in T-ALL [98]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.