MYC and acute lymphoblastic leukemia: Although initial experiments failed to determine an active role of NOTCH1 on MYC promoter regulation, deeper chromatin immunoprecipitation (ChIP) analysis in T-ALL led to the identification of a T-cell-specific distal genomic region located >1 Mb 3′ of human and murine MYC locus strongly occupied by NOTCH transcription complexes, which physically interacts with the regulatory sequences in the MYC proximal promoter [108,197].