Besides its contribution to myeloid development, particularly to granulocyte and macrophage differentiation and to the pathogenesis of acute myeloid leukemia (AML) [117], miR-223 is induced by active NOTCH1 and participates in T-ALL leukemogenesis by repressing the tumor suppressor FBXW7 [118]. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.