An additional human T-ALL model has also been described by Weng’s group in NSG mice transplanted with CD34+ CB HPCs cotransduced with NOTCH1-ΔE mutants together with a combination of oncogenes identified in T-ALL patients, i.e., LMO2, TAL1 and BMI1 (LTB) [93], allowing to study the collaboration of these mutations with the NOTCH1 oncogenic program. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.