PTEN and acute lymphoblastic leukemia: Accordingly, several miRNAs (miR-19b, miR-20a, miR-26a, miR-92, and miR-223) accelerate leukemia progression when coexpressed with NICD in a mouse T-ALL model [95] through a mechanism involving specific targeting of T-ALL tumor suppressor genes including Pten, Bim, Nf1, Fbxw7, Ikzf1 and Phf6. Hence, these miRNAs were categorized as T-ALL oncomiRs.