Consequently, NOTCH1-induced T-ALL pathogenesis and/or disease maintenance and progression were shown to be dependent on CCND3, CDK4 and CDK6 gene expression [109,110] and on down-regulation of the cyclin-dependent kinase inhibitors CDKN2D (p19INK4d) and CDKN1B (p27Kip1) [229]. This evidence concerns the gene CDK6 and acute lymphoblastic leukemia.