GATA3 and acute lymphoblastic leukemia: Early T-lineage progenitor (ETP) T-ALL, which is characterized by a very immature CD4− CD8− DN T-cell phenotype and the coexpression of stem cell and myeloid-associated markers [47], commonly harbor mutations in epigenetic regulators (EZH2, IDH1, IDH2, DNMT3A), transcription factors associated to hematopoietic and T-cell development (ETV6, GATA3, RUNX1), and signaling pathways such NRAS and FLT3 [48].