LYVE1 and neoplasm: There have been various studies on the relationship between lymphangiogenesis and malignant diseases, including the mechanism underlying tumor-induced lymphangiogenesis with VEGF-C/D and LYVE-1 [91,92], the mechanism underlying tumor-induced lymphangiogenesis before tumor metastasis in sentinel lymph nodes [93,94], and the correlation between increased tumor-induced lymphangiogenesis and poor prognosis [95].