During the recruitment of immune suppressive cells to the lymph nodes, immune cells, such as myeloid-derived suppressor cells, tumor-associated macrophages, regulatory T cells, and immature dendritic cells, are mobilized and suppress the activation of CD4+ or CD8+ T cells and NK cells; as a result, these immune suppressive cells promote tumor metastasis [110,111]. The gene discussed is CD8A; the disease is neoplasm.