In addition, several studies have shown that EVs from highly malignant tumor cells transfer their specific mutant genes or molecules, such as mutant KRAS in colon cancer, long noncoding RNA (lncRNA) ZFAS1 in gastric cancer, or esophageal squamous cell carcinoma (ESCC), and lncRNA ZEB1-AS1 in ESCC, to wild-type cells [36,37,38]. This evidence concerns the gene ZEB1 and esophageal squamous cell carcinoma.