Tumor lesions progress according to such a process, and tumor cell-derived EVs are also associated with the immune system in various ways, for example, by suppressing the proliferation of CD8+ T cells [56,57] or by expressing the ligands that bind to death receptors, such as Fas and TNFα, and thus inducing T-cell apoptosis [58]. The gene discussed is CD8A; the disease is neoplasm.