Similarly, several cargoes of EVs, such as the heparin-binding factor midkine in melanoma-derived EVs [98], ELNAT1 in bladder cancer-derived EVs [99], and the lncRNA HANR in hepatocellular carcinoma-derived EVs [100], promote lymphangiogenesis by inducing VEGF-C or VEGFR-3. The gene discussed is VEGFC; the disease is urinary bladder cancer.