Moreover, IL6 mRNA expression was significantly increased in Plaur-/- mice 14 days after bleomycin instillation (p < 0.05, 2-way ANOVA, Holm–Šídák’s test, Figure 6C), confirming uPA and IL-6 in lung fibrosis to be intertwined and closely linked. The gene discussed is PLAU; the disease is pulmonary fibrosis.