Collagen progressively accumulated after bleomycin-induced pulmonary fibrosis in all mice; collagen was intensively deposited in both Plau-/- and Plaur-/- deficient mice starting from day 7 and throughout the whole observation period (2-way ANOVA, Holm–Šídák’s test, p < 0.0001, Figure 5F). The gene discussed is PLAU; the disease is pulmonary fibrosis.