However, a significant increase in Acta2 expression (encodes for α-smooth muscle actin, a mesenchymal marker) was revealed in Plaur-/- mice on Day 14 and Day 21 of bleomycin-induced pulmonary fibrosis (2-way ANOVA, Holm–Šídák’s test, p < 0.05, Figure 7C). This evidence concerns the gene ACTA2 and pulmonary fibrosis.