For the first time, we demonstrated that the introduction of the external plasminogen could indeed disrupt this vicious circle and reverse lung fibrosis in the absence of uPAR: the intravenous injection of 1 mg of plasminogen on the 21st day of bleomycin-induced fibrosis in Plaur-/- mice resulted in a 2-fold reduction in the fibrosis area in the lungs as compared to the non-treated mice by day 42 (Figure 9). This evidence concerns the gene PLAUR and fibrosis.