Previously, it was reported that the reduced serum levels of plasminogen and PAI-1 were significantly associated with low survival in severely ill COVID-19 patients [27,28], while high soluble uPAR serum level was shown to be an early predictor of clinical severity and poor outcome in patients with COVID-19 [29,30,31,32,33,34]. Here, SERPINE1 is linked to COVID-19.