AQP3 is an important protein that regulates keratinocyte proliferation, differentiation, and migration, as well as skin hydration and water permeability repair in vivo, and dysregulation of AQP3 leads to impaired wound healing [10,11,12,13,14,15,16,17,18,19,20] and xerosis [10,22]. Here, AQP3 is linked to Dry skin.