MAPT and Mental deterioration: However, a recent cross-sectional study [20] using a large sample of community-dwelling individuals reported that CSF Aβ42, T-tau/Aβ42 and p-tau/Aβ42 levels were associated with depression, and a prospective study including subjective cognitive decline (SCD) participants of the German Dementia Competence Network (DCN) study, CSF Aβ42 was found associated with an increment in depression severity over time [21].