ADORA2A and Parkinson disease: Furthermore, recent studies show that the A2AR blockade decreases α-Syn aggregation in Syn T-Synphilin-1 neuroglioma cells [57] and rescues synaptic and cognitive deficits in α-Syn-transgenic mice [58], and A2AR gene disruption protects in the α-Syn model of PD by preventing the loss of dopamine and dopaminergic neurons [59].