More recently, recurrent hairy/enhancer-of-split related with YRPW motif 1—nuclear receptor coactivator 2 (HEY1-NCOA2) and interferon regulatory factor 2 binding protein 2 gene—caudal type homeobox 1 (IRF2BP2-CDX1) fusions have been identified in mesenchymal chondrosarcomas [21,22]. This evidence concerns the gene HEY1 and mesenchymal chondrosarcoma.