Although the exact mechanism of action of ABCA5 in CRC is not confirmed, this study could indicate the possible role of ABCA5 in the progression of CRC cancer either by acting as a pump to efflux drugs out of the cells or, as another study mentioned, it could have a possible function in thyroid hormone homeostasis [44]; an example of that is thyroxine (T4), which can possibly promote the development of CRC [45]. The gene discussed is TG; the disease is colorectal carcinoma.