ABCB1 and colonic neoplasm: On the other hand, ABCB1 was also found to modulate the resistance to apoptosis [40,41] and control cell proliferation in CRC, and the suppression of ABCB1 in a colon cancer cell line was demonstrated to inhibit proliferation by resulting in a G0/G1 phase cell cycle arrest in both in vitro and in vivo studies [42].