MPO and Autoimmunity: Mice were administered a sub-nephritogenic dose of sheep anti-mouse GBM globulin, which does not induce kidney injury if injected into naïve mice, but will only trigger glomerulonephritis in mice with established autoimmunity to MPO by recruiting neutrophils to the glomerulus where they degranulate, depositing MPO triggering anti-MPO T cell recall responses [36].