TF and cancer: TFs are desirable targets for cancer therapy for several reasons: (1) their dysregulation tends to occur in early stage tumorigenesis; (2) perturbation of TF-driven transcriptional programs can block differentiation of cancer cells and prevent cell death of cancer cells; and (3) TFs play a pivotal role in the establishment and maintenance of oncogenic gene expression networks; thus, it is more difficult for cancer cells to bypass their inhibition/inactivation by activating alternative pathways [5,6,7,8].