The active involvement of the CNR1 promoter region was further supported by analysis of the CNR1 promoter on-line data repositories (UCSC genome database), which revealed active promoter markers such as histone modification marks (H3K4me3), binding of the core transcriptional apparatus (RNA polymerase II) and DNAaseI hypersensitivity binding sites are all present within the CNR1 promoter region in cell lines from which neuroblastomas such as SH-SY5Y cells are derived [40,41,42,43]. Here, CNR1 is linked to neuroblastoma.