From this perspective, the administration of flavonoids, which exhibit a relatively wide spectrum of beneficial effects, such as promoting anti-oxidation (as mentioned in case of the, e.g., mitochondrial BK channel modulation) and immunosuppression (as discussed in Section 2), seems reasonable especially for the high-risk populations, e.g., suffering T2D [220,221] or endocrinopathies [224,225,226]. Here, KCNMA1 is linked to endocrine system disorder.