Similarly, another study identified and termed an unannotated lncRNA, HORAS, by analyzing PCa PDX models and found that HORAS5 was significantly upregulated in castration-resistant PDXs, considerably expressed only in AR-positive CRPC-derived cell lines and promoted the proliferation and migration potential of CRPC-derived cells by maintaining AR activity in the absence of androgen [59]. Here, AR is linked to posterior cortical atrophy.