CD274 and neoplasm: Activating mutations in the Wnt/b-catenin pathway can also induce resistance to ICI through altering the expression of PD-L1 and PD-L2 in a broad group of tumors [140,141] and mechanistic studies specifically in melanoma have revealed that Wnt-induced decrease in the expression of the chemokine CCL4 hindered the recruitment of CD103+ DCs and T cells to the tumor microenvironment [142].