If the HIF-1α content is high, it points to oncological or cardiovascular diseases: hypoxia, strokes, heart attacks, pulmonary hypertension, etc. [10,11,12,13,14,15], which disturb, along with concomitant diseases, the self-regulation of HIF-1α and its stabilization [13]. Here, HIF1A is linked to pulmonary arterial hypertension.