CD4 and multiple sclerosis: The main single nucleotide polymorphisms (SNVs) in LAG3 and CD4 genes have been related to protection against the severity of primary immune thrombocytopenia (LAG3 rs870849 T>C) [6], comorbidity in multiple sclerosis (CD4 rs1922452 A>G) [7], and disease progression and mortality of sepsis (CD4 rs951818 C>A) [8].