More recently, we showed that a rise in [Ca2+]i also induced a sequential phosphorylation of PKCα and the downstream series of phosphorylation of p38MAPK and p42/44 MAPK, resulting in Ca2+-dependent genes, such as profibrotic ECM genes, and, ultimately, the proliferation of glaucoma LC cells [29]. This evidence concerns the gene PRKCA and glaucoma.