Here, we have reported three main findings that are distinct from previous studies: (1) proteomic changes in retinal protein were the most significant in the far-periphery retina after myopia induction, followed by the central retina; (2) coagulation regulation, complement, and coagulation cascades were the most significant and upregulated biological process for myopia induction in the far-periphery retina; and (3) antithrombin-III (SERPINC1), fibrinogen gamma chain (FGG), and fibrinogen beta chain (FGB) are potential novel biomarkers for myopia induction in the retina. This evidence concerns the gene SERPINC1 and myopia.