The signature (NLRP9, DHX9, CASP3, NLRC4, AIM2, NLRP3, IL1B, GSDM E and GSDM D) demonstrates powerfulness as a melanoma diagnosis tool, and separated with high accuracy primary melanoma patients from subjects suffering from common nevi belonging to an independent (GSE98394) dataset. Here, DHX9 is linked to melanoma.