By applying the GEPIA2 online software to the expression levels of GSDM and inflammasome-related genes extracted from TCGA and GEO (for melanoma patients) and GTEx (for normal skin subjects) databases, a gene signature associated with PYR was defined, including AIM2, GSDM C, GSDM D, IL18, NLRP6 and PRKACA). This evidence concerns the gene GSDMA and melanoma.