The signature (NLRP9, DHX9, CASP3, NLRC4, AIM2, NLRP3, IL1B, GSDM E and GSDM D) demonstrates powerfulness as a melanoma diagnosis tool, and separated with high accuracy primary melanoma patients from subjects suffering from common nevi belonging to an independent (GSE98394) dataset. This evidence concerns the gene CASP3 and melanoma.