The expression levels of a set of PYR-related genes from melanoma patients (TCGA and GSE65904) and healthy individuals (GTEx) were considered by Meng and co-workers for the definition of a signature including 12 differentially expressed genes (AIM2, IL1B, NLRC4, NLRP3, NLRP6, NLRP7, TNF, ELANE, GSDM A, GSDM B, GSDM C, NLRP1) [96]. This evidence concerns the gene NLRP3 and melanoma.