NPPA and heart failure: Here, we found that 6 days of high-dose ISO incubation was able to cause the overexpression of the heart failure markers Nppa, Nppb, and Trl4; the significant downregulation of the RBFox2 protein; repression of the alternative splicing in the Enah gene; and the suppression of the Jph2 protein in NRCMs (See Figure 5).