The lower part contained the nodes related to inflammation and the cell junction, including Tlr4, a key immune receptor that is increased in heart failure and that plays a critical role in myocardial inflammation [34]; Serping1, a serine proteinase inhibitor that reduces inflammation and damage in post-myocardial infraction [35]; and Cdh5, a junction protein exhibiting a cardioprotective role in stress-induced hypoxia or ischemia [36]. Here, CDH5 is linked to heart failure.