RBFOX2 and heart failure: In this case, the overexpression of corresponding miRNAs resulted in a ~50% reduction in the RBFox2 protein (Figure 4A and Supplementary Figure S4B,C), which is comparable to previous results from the heart failure stage in the TAC model (Figure 3A), whereas direct siRNA interference could repress ~80% of the RBFox2 protein.