ACTA1 and heart failure: Interestingly, the nodes encoded by upregulated genes (red) were functionally aggregated in the upper left, including the gold-standard biomarkers (Nppa and Nppb) involved in heart failure diagnosis [23], the molecular markers (Myh7 and Acta1) elevated from the hypertrophic state [26,27], and other cardiac cytoskeleton proteins (Myot and Tpm2) related to heart failure [28,29].