UBE4A and Alzheimer disease: The pathophysiological relevance of these findings is supported by the fact that among the regulatory genes for amyloid toxicity identified, there are 10 genes that have been proposed in GWAS as playing an important role in AD: AQP9 [34,35], HSPA1B [34,36], HSPA1L [34,37], OSBPL10 [34,38], AP3M2 [34,39], GAS7 [34,40], KMO [34,41], RAB5A [34,42], UBE4A [34,43] and VSP28 [34].