To elucidate the effect of SURF4 in SOCE, we transfected human neuroblastoma cells with either a selective siRNA for silencing SURF4 (Figure 6A) or a plasmid to express SURF4 (Figure 6D), which resulted in a significant decrease (Figure 6A) or increase in mRNA SURF4 expression (Figure 6D), respectively. The gene discussed is SURF4; the disease is neuroblastoma.