Strong widespread expression of p53 consistent with mutant p53 was assigned to 56% of breast metastases (n = 15/27), 86% of colorectal metastases (n = 18/21), 39% of lung metastases (n = 18/46) and 41% of melanoma metastases (n = 19/46). The gene discussed is TP53; the disease is melanoma.