ITGA5 and cancer: To determine whether cancer-promoting proteins were increased on the Δ133p53 cell surface, proto-oncogenes or proteins induced by proto-oncogenes in lung cancer, including c-MET, VEGFR, ITGα5, EGFR, TFRC and ALK, were measured on the cell surface of Δ133p53α and Δ133p53β cell lines using flow cytometry (Figure 7a–c).