There were the following multiple perspectives about the anti-cancer mechanism of NAMI-A and its derivatives: (i) interacting with DNA forming the bifunctional intrastrand adducts on double helical DNA [115], (ii) mimicking Fe(III) behaviors to overcome the selective transferrin recognition to the entry of cancer cells [116], (iii) acting as anti-angiogenic agent [117], (iv) binding to collagen of the extracellular matrix and cell surface integrins [112]. Here, TF is linked to cancer.