We demonstrated that platinum resistance, which is mediated by cisplatin-induced ERCC-1, MRP-2, and XIAP in SKOV3 ovarian cancer cells (with a moderate level of HOXB9 expression), could be overcome by cisplatin treatment alone through the inhibition of Bcl-2 and activation of Bax. The gene discussed is XIAP; the disease is ovarian carcinoma.