CREB3 and neoplasm: Overexpression of FRA-1 (encoded by the FOSL1 gene), a leucine zipper protein forming the transcription factor complex AP-1, can promote tumor dissemination due to its possible role in EMT-like processes, and metastatic spreading, by driving the expression of EMT-inducing transcription factors, cytokines, and microRNAs [3,4,18,84].