Development of a co-expression and competitive endogenous RNA network of cirRNAs that are significantly deregulated in prostate cancer samples revealed that the EMT transcription factor SMAD4 may be partially regulated by miR-1285 (which was detected in EV PIC); additionally, hsa-cir-0001206 binding of miR-1285 inhibits prostate cancer cell proliferation, migration, and invasion [70]. This evidence concerns the gene SMAD4 and Familial prostate cancer.