In addition, FAT10 is known to regulate several pathways, such as NF-κB, Akt, or Wnt signaling, involved in cancer development, and also to directly interact with downstream targets, such as p53, β-catenin, SMAD2, and MAD2, leading to enhanced survival, proliferation, invasion, and metastasis formation of cancer cells but also of non-malignant cells [64]. The gene discussed is SMAD2; the disease is cancer.