UBL3 is downregulated in non-small-cell lung cancer, gastric cancer, esophageal cancer, and pancreatic cancer and it has been identified as a tumor suppressor in NSCLC, while in breast cancer, it is a susceptibility gene for high-risk breast cancer and is an MAP3K8 fusion partner in melanocytic tumors. Here, UBL3 is linked to esophageal cancer.