Actually, the presence of phosphorylated TDP-43 accumulated intraneuronal in regions such as the amygdala, at first, and later extended to the hippocampal regions and the rest of the brain parenchymal, appearing in the entity called the TDP-43 encephalopathy neuropathological change (LATE-NC), which is related to aging [36]. The gene discussed is TARDBP; the disease is nevus comedonicus syndrome.