Related to the importance of DRP1 in response to chemotherapy in ovarian cancer, several studies have evaluated the possibility of use, in combination with chemotherapy, of various phytochemicals such as piperlongumine, piceatannol, and sambucus nigra agglutinin, that can induce mitochondrial fission by decreasing DRP1 phosphorylation Ser637 and increasing DRP1 and FIS1 mRNA levels [124,125,126]. The gene discussed is DNM1L; the disease is ovarian carcinoma.