HSD17B6 and neoplasm: Meanwhile, for the oxidizing enzymes involved in E1 biosynthesis, tumoural overexpression of HSD17B4, HSD17B6 and HSD17B14 resulted in lower ovarian cancer PFS; overexpression of HSD17B4 and HSD17B6 in ovarian primary tumours were related to decreased PPS, and high expression of the oxidative enzymes HSD17B4, HSD17B6 and HSD17B14 correlated with reduced OS.