Meanwhile, for the oxidizing enzymes involved in E1 biosynthesis, tumoural overexpression of HSD17B4, HSD17B6 and HSD17B14 resulted in lower ovarian cancer PFS; overexpression of HSD17B4 and HSD17B6 in ovarian primary tumours were related to decreased PPS, and high expression of the oxidative enzymes HSD17B4, HSD17B6 and HSD17B14 correlated with reduced OS. The gene discussed is HSD17B4; the disease is ovarian cancer.