Further HFD intervention on 12-KC resulted in a significant decrease in the density of Hand-Gal4>skd RNAi-12D-HFD-C (12-KHC) Drosophila cardiac myocardial fibers, whose arrangement appeared very disorganized and even fiber loss in some places and thinning of the heart tube diameter (Figure 2B). The gene discussed is MIB2; the disease is keratoconus.