It has been found that severity of the disease increases with aging and demonstrated [3] that increased adhesion molecule ICAM-1 expression can increase virus entry in COVID-19 due to increased tissue permeability, and at the same time, increased adhesion molecule ICAM-1 expression can increase the risk of cardiovascular diseases due to tight junction integrity disruption and the increased transmigration of neutrophils [2], Figure 1. The gene discussed is ICAM1; the disease is cardiovascular disorder.