SREBF1 and hepatocellular carcinoma: PNLA downregulated the expression of genes related to FA biosynthesis (fatty acid synthase (FAS), sterol regulatory element-binding protein 1(SREBP1), and stearoyl-CoA desaturase 1 (SCD1)) in the human hepatoma cell line (HepG2) when compared to control (53, 54, and 38% lower, respectively).