Since L-lactate has been shown to enhance cognitive function (learning and long-term memory) and exert neuroprotective effects in models of ischemia and exitotoxicity [39,40,41]), the intensification of GPR81 levels in the hippocampus seems to be, as in the case of MPC1 and MPC2 transporters, a favorable change. Here, HCAR1 is linked to ischemia.