SOX2 and Neurodevelopmental delay: Bertolini et al. [15] used a different approach, i.e., RNApolII-ChIA-PET, to profile RNA-polII-mediated long-range interactions in the chromatin of ex vivo neural stem/progenitor cells (NSC) from the mouse neonatal forebrain, in the normal (wild-type) and in mice in which the SOX2 transcription factor-encoding gene (whose mutation causes NDD in humans) had been deleted in the developing nervous system via a Nestin-Cre transgene ([29], see also [30]).