EGF-like domains have previously been identified in the globular domains of members of the lectican CS-PG family and shown to promote cell proliferation and migration in some cancers [393,394,395] however the specific roles of the EGF-like domains in the HS-PGs have not been ascertained, it is not known if these also contribute to cell proliferation and migration promoted by HS-PGs. Here, EGF is linked to cancer.