The models described for CSS include the Staphylococcal superantigen mutant model in rabbits [82], the hemolytic transfusion model in mice [83], and the reactions of dogs to anti-CD28 mAb [84], primates to simian immunodeficiency virus [85], or pigs to a virulent African swine fever virus [86], yet another porcine model utilized LPS to induce CSS along with ARDS [87]. This evidence concerns the gene CD28 and acute respiratory distress syndrome.