This finding was further assessed through RT-PCR on freshly isolated CMs from the T1DM, T2DM and CTRL mice, where the expression levels of the apoptotic gene markers Bax, Casp3, Bcl2, Foxo3 and Foxo1 were higher in the T1DM versus T2DM mice and in the T1DM and T2DM mice versus the CTRL mice (Figure 3B). Here, FOXO3 is linked to type 1 diabetes mellitus.