SOD1 and amyotrophic lateral sclerosis: Gene therapy with riluzole and edaravone, the only two known agents shown to slow down disease progression in ALS, for two forms of the disease—one caused by mutations in the C9orf72 gene and the form related to superoxide dismutase 1 (SOD1) Cu/Zn—may be a promising treatment therapy in the case of failure of pharmacological approaches.