We found two pathogenic de novo missense variants in PCDH19, the gene related to developmental and epileptic encephalopathy (DEE), type 9 (DEE-9), c.688G>A, and c.1813T>C in two female patients (9 and 12, respectively) who developed epilepsy, developmental regression, and moderate intellectual disability (ID). This evidence concerns the gene PCDH19 and epilepsy.